Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.
Identifieur interne : 000093 ( Main/Exploration ); précédent : 000092; suivant : 000094Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.
Auteurs : Ahmed Mostafa [Allemagne, Égypte] ; El-Sayed M. Abdelwhab [Allemagne] ; Heiko Slanina [Allemagne] ; Mohamed A. Hussein [Égypte] ; Irina Kuznetsova [Allemagne] ; Christian G. Schüttler [Allemagne] ; John Ziebuhr [Allemagne] ; Stephan Pleschka [Allemagne]Source :
- Archives of virology [ 1432-8798 ] ; 2016.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Allemagne (épidémiologie), Dérive génétique (MeSH), Enfant (MeSH), Femelle (MeSH), Glycoprotéine hémagglutinine du virus influenza (composition chimique), Glycoprotéine hémagglutinine du virus influenza (génétique), Glycosylation (MeSH), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Jeune adulte (MeSH), Modèles moléculaires (MeSH), Mâle (MeSH), Phylogenèse (MeSH), Sous-type H3N2 du virus de la grippe A (classification), Sous-type H3N2 du virus de la grippe A (génétique), Sous-type H3N2 du virus de la grippe A (isolement et purification), Structure tertiaire des protéines (MeSH), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Sélection génétique (MeSH), Vaccins antigrippaux (génétique), Variation génétique (MeSH).
- MESH :
- composition chimique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H3N2 du virus de la grippe A.
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H3N2 du virus de la grippe A, Vaccins antigrippaux.
- isolement et purification : Sous-type H3N2 du virus de la grippe A.
- virologie : Grippe humaine.
- épidémiologie : Allemagne, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Dérive génétique, Enfant, Femelle, Glycosylation, Humains, Jeune adulte, Modèles moléculaires, Mâle, Phylogenèse, Structure tertiaire des protéines, Sujet âgé, Sujet âgé de 80 ans ou plus, Sélection génétique, Variation génétique.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Child (MeSH), Female (MeSH), Genetic Drift (MeSH), Genetic Variation (MeSH), Germany (epidemiology), Glycosylation (MeSH), Hemagglutinin Glycoproteins, Influenza Virus (chemistry), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans (MeSH), Influenza A Virus, H3N2 Subtype (classification), Influenza A Virus, H3N2 Subtype (genetics), Influenza A Virus, H3N2 Subtype (isolation & purification), Influenza Vaccines (genetics), Influenza, Human (epidemiology), Influenza, Human (virology), Male (MeSH), Middle Aged (MeSH), Models, Molecular (MeSH), Phylogeny (MeSH), Protein Structure, Tertiary (MeSH), Selection, Genetic (MeSH), Young Adult (MeSH).
- MESH :
- chemical , chemistry : Hemagglutinin Glycoproteins, Influenza Virus.
- classification : Influenza A Virus, H3N2 Subtype.
- epidemiology : Germany, Influenza, Human.
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H3N2 Subtype, Influenza Vaccines.
- isolation & purification : Influenza A Virus, H3N2 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Aged, Aged, 80 and over, Child, Female, Genetic Drift, Genetic Variation, Glycosylation, Humans, Male, Middle Aged, Models, Molecular, Phylogeny, Protein Structure, Tertiary, Selection, Genetic, Young Adult.
Abstract
Infections by H3N2-type influenza A viruses (IAV) resulted in significant numbers of hospitalization in several countries in 2014-2015, causing disease also in vaccinated individuals and, in some cases, fatal outcomes. In this study, sequence analysis of H3N2 viruses isolated in Germany from 1998 to 2015, including eleven H3N2 isolates collected early in 2015, was performed. Compared to the vaccine strain A/Texas/50/2012 (H3N2), the 2015 strains from Germany showed up to 4.5 % sequence diversity in their HA1 protein, indicating substantial genetic drift. The data further suggest that two distinct phylogroups, 3C.2 and 3C.3, with 1.6-2.3 % and 0.3-2.4 % HA1 nucleotide and amino acid sequence diversity, respectively, co-circulated in Germany in the 2014/2015 season. Distinct glycosylation patterns and amino acid substitutions in the hemagglutinin and neuraminidase proteins were identified, possibly contributing to the unusually high number of H3N2 infections in this season and providing important information for developing vaccines that are effective against both genotypes.
DOI: 10.1007/s00705-016-2815-x
PubMed: 26973232
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.</title><author><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Dokki, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Abdelwhab, El Sayed M" sort="Abdelwhab, El Sayed M" uniqKey="Abdelwhab E" first="El-Sayed M" last="Abdelwhab">El-Sayed M. Abdelwhab</name><affiliation wicri:level="1"><nlm:affiliation>Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute, Suedufer 10, 17493, Greifswald, Insel-Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute, Suedufer 10, 17493, Greifswald, Insel-Riems</wicri:regionArea><wicri:noRegion>Insel-Riems</wicri:noRegion><wicri:noRegion>Insel-Riems</wicri:noRegion><wicri:noRegion>Insel-Riems</wicri:noRegion></affiliation></author><author><name sortKey="Slanina, Heiko" sort="Slanina, Heiko" uniqKey="Slanina H" first="Heiko" last="Slanina">Heiko Slanina</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Hussein, Mohamed A" sort="Hussein, Mohamed A" uniqKey="Hussein M" first="Mohamed A" last="Hussein">Mohamed A. Hussein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Poultry Diseases, National Research Centre (NRC), Dokki, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Poultry Diseases, National Research Centre (NRC), Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Kuznetsova, Irina" sort="Kuznetsova, Irina" uniqKey="Kuznetsova I" first="Irina" last="Kuznetsova">Irina Kuznetsova</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Schuttler, Christian G" sort="Schuttler, Christian G" uniqKey="Schuttler C" first="Christian G" last="Schüttler">Christian G. Schüttler</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Pleschka, Stephan" sort="Pleschka, Stephan" uniqKey="Pleschka S" first="Stephan" last="Pleschka">Stephan Pleschka</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany. stephan.pleschka@viro.med.uni-giessen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26973232</idno><idno type="pmid">26973232</idno><idno type="doi">10.1007/s00705-016-2815-x</idno><idno type="wicri:Area/Main/Corpus">000100</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000100</idno><idno type="wicri:Area/Main/Curation">000100</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000100</idno><idno type="wicri:Area/Main/Exploration">000100</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.</title><author><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Dokki, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Abdelwhab, El Sayed M" sort="Abdelwhab, El Sayed M" uniqKey="Abdelwhab E" first="El-Sayed M" last="Abdelwhab">El-Sayed M. Abdelwhab</name><affiliation wicri:level="1"><nlm:affiliation>Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute, Suedufer 10, 17493, Greifswald, Insel-Riems, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute, Suedufer 10, 17493, Greifswald, Insel-Riems</wicri:regionArea><wicri:noRegion>Insel-Riems</wicri:noRegion><wicri:noRegion>Insel-Riems</wicri:noRegion><wicri:noRegion>Insel-Riems</wicri:noRegion></affiliation></author><author><name sortKey="Slanina, Heiko" sort="Slanina, Heiko" uniqKey="Slanina H" first="Heiko" last="Slanina">Heiko Slanina</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Hussein, Mohamed A" sort="Hussein, Mohamed A" uniqKey="Hussein M" first="Mohamed A" last="Hussein">Mohamed A. Hussein</name><affiliation wicri:level="1"><nlm:affiliation>Department of Poultry Diseases, National Research Centre (NRC), Dokki, Giza, Egypt.</nlm:affiliation><country xml:lang="fr">Égypte</country><wicri:regionArea>Department of Poultry Diseases, National Research Centre (NRC), Dokki, Giza</wicri:regionArea><wicri:noRegion>Giza</wicri:noRegion></affiliation></author><author><name sortKey="Kuznetsova, Irina" sort="Kuznetsova, Irina" uniqKey="Kuznetsova I" first="Irina" last="Kuznetsova">Irina Kuznetsova</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Schuttler, Christian G" sort="Schuttler, Christian G" uniqKey="Schuttler C" first="Christian G" last="Schüttler">Christian G. Schüttler</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Pleschka, Stephan" sort="Pleschka, Stephan" uniqKey="Pleschka S" first="Stephan" last="Pleschka">Stephan Pleschka</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany. stephan.pleschka@viro.med.uni-giessen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen</wicri:regionArea><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>35392, Giessen</wicri:noRegion><wicri:noRegion>Giessen</wicri:noRegion></affiliation></author></analytic><series><title level="j">Archives of virology</title><idno type="eISSN">1432-8798</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Child (MeSH)</term><term>Female (MeSH)</term><term>Genetic Drift (MeSH)</term><term>Genetic Variation (MeSH)</term><term>Germany (epidemiology)</term><term>Glycosylation (MeSH)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (chemistry)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H3N2 Subtype (classification)</term><term>Influenza A Virus, H3N2 Subtype (genetics)</term><term>Influenza A Virus, H3N2 Subtype (isolation & purification)</term><term>Influenza Vaccines (genetics)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (virology)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Models, Molecular (MeSH)</term><term>Phylogeny (MeSH)</term><term>Protein Structure, Tertiary (MeSH)</term><term>Selection, Genetic (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Allemagne (épidémiologie)</term><term>Dérive génétique (MeSH)</term><term>Enfant (MeSH)</term><term>Femelle (MeSH)</term><term>Glycoprotéine hémagglutinine du virus influenza (composition chimique)</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycosylation (MeSH)</term><term>Grippe humaine (virologie)</term><term>Grippe humaine (épidémiologie)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Modèles moléculaires (MeSH)</term><term>Mâle (MeSH)</term><term>Phylogenèse (MeSH)</term><term>Sous-type H3N2 du virus de la grippe A (classification)</term><term>Sous-type H3N2 du virus de la grippe A (génétique)</term><term>Sous-type H3N2 du virus de la grippe A (isolement et purification)</term><term>Structure tertiaire des protéines (MeSH)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Sélection génétique (MeSH)</term><term>Vaccins antigrippaux (génétique)</term><term>Variation génétique (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Germany</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinin Glycoproteins, Influenza Virus</term><term>Influenza A Virus, H3N2 Subtype</term><term>Influenza Vaccines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéine hémagglutinine du virus influenza</term><term>Sous-type H3N2 du virus de la grippe A</term><term>Vaccins antigrippaux</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H3N2 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H3N2 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Allemagne</term><term>Grippe humaine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Child</term><term>Female</term><term>Genetic Drift</term><term>Genetic Variation</term><term>Glycosylation</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Molecular</term><term>Phylogeny</term><term>Protein Structure, Tertiary</term><term>Selection, Genetic</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Dérive génétique</term><term>Enfant</term><term>Femelle</term><term>Glycosylation</term><term>Humains</term><term>Jeune adulte</term><term>Modèles moléculaires</term><term>Mâle</term><term>Phylogenèse</term><term>Structure tertiaire des protéines</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Sélection génétique</term><term>Variation génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Infections by H3N2-type influenza A viruses (IAV) resulted in significant numbers of hospitalization in several countries in 2014-2015, causing disease also in vaccinated individuals and, in some cases, fatal outcomes. In this study, sequence analysis of H3N2 viruses isolated in Germany from 1998 to 2015, including eleven H3N2 isolates collected early in 2015, was performed. Compared to the vaccine strain A/Texas/50/2012 (H3N2), the 2015 strains from Germany showed up to 4.5 % sequence diversity in their HA1 protein, indicating substantial genetic drift. The data further suggest that two distinct phylogroups, 3C.2 and 3C.3, with 1.6-2.3 % and 0.3-2.4 % HA1 nucleotide and amino acid sequence diversity, respectively, co-circulated in Germany in the 2014/2015 season. Distinct glycosylation patterns and amino acid substitutions in the hemagglutinin and neuraminidase proteins were identified, possibly contributing to the unusually high number of H3N2 infections in this season and providing important information for developing vaccines that are effective against both genotypes. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26973232</PMID><DateCompleted><Year>2017</Year><Month>01</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>01</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-8798</ISSN><JournalIssue CitedMedium="Internet"><Volume>161</Volume><Issue>6</Issue><PubDate><Year>2016</Year><Month>Jun</Month></PubDate></JournalIssue><Title>Archives of virology</Title><ISOAbbreviation>Arch. Virol.</ISOAbbreviation></Journal><ArticleTitle>Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.</ArticleTitle><Pagination><MedlinePgn>1505-15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00705-016-2815-x</ELocationID><Abstract><AbstractText>Infections by H3N2-type influenza A viruses (IAV) resulted in significant numbers of hospitalization in several countries in 2014-2015, causing disease also in vaccinated individuals and, in some cases, fatal outcomes. In this study, sequence analysis of H3N2 viruses isolated in Germany from 1998 to 2015, including eleven H3N2 isolates collected early in 2015, was performed. Compared to the vaccine strain A/Texas/50/2012 (H3N2), the 2015 strains from Germany showed up to 4.5 % sequence diversity in their HA1 protein, indicating substantial genetic drift. The data further suggest that two distinct phylogroups, 3C.2 and 3C.3, with 1.6-2.3 % and 0.3-2.4 % HA1 nucleotide and amino acid sequence diversity, respectively, co-circulated in Germany in the 2014/2015 season. Distinct glycosylation patterns and amino acid substitutions in the hemagglutinin and neuraminidase proteins were identified, possibly contributing to the unusually high number of H3N2 infections in this season and providing important information for developing vaccines that are effective against both genotypes. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mostafa</LastName><ForeName>Ahmed</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Dokki, Giza, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdelwhab</LastName><ForeName>El-Sayed M</ForeName><Initials>el-SM</Initials><AffiliationInfo><Affiliation>Federal Research Institute for Animal Health, Friedrich-Loeffler-Institute, Suedufer 10, 17493, Greifswald, Insel-Riems, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slanina</LastName><ForeName>Heiko</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hussein</LastName><ForeName>Mohamed A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Poultry Diseases, National Research Centre (NRC), Dokki, Giza, Egypt.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuznetsova</LastName><ForeName>Irina</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schüttler</LastName><ForeName>Christian G</ForeName><Initials>CG</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ziebuhr</LastName><ForeName>John</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pleschka</LastName><ForeName>Stephan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Institute of Medical Virology, Justus Liebig University Giessen, Schubertstrasse 81, 35392, Giessen, Germany. stephan.pleschka@viro.med.uni-giessen.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>03</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Austria</Country><MedlineTA>Arch Virol</MedlineTA><NlmUniqueID>7506870</NlmUniqueID><ISSNLinking>0304-8608</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019267">Hemagglutinin Glycoproteins, Influenza Virus</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007252">Influenza Vaccines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D040961" MajorTopicYN="N">Genetic Drift</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014644" MajorTopicYN="N">Genetic Variation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005858" MajorTopicYN="N">Germany</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006031" MajorTopicYN="N">Glycosylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019267" MajorTopicYN="N">Hemagglutinin Glycoproteins, Influenza Virus</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053122" MajorTopicYN="N">Influenza A Virus, H3N2 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007252" MajorTopicYN="N">Influenza Vaccines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017434" MajorTopicYN="N">Protein Structure, Tertiary</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012641" MajorTopicYN="N">Selection, Genetic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>11</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>02</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>3</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>1</Month><Day>31</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26973232</ArticleId><ArticleId IdType="doi">10.1007/s00705-016-2815-x</ArticleId><ArticleId IdType="pii">10.1007/s00705-016-2815-x</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Égypte</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name></noRegion><name sortKey="Abdelwhab, El Sayed M" sort="Abdelwhab, El Sayed M" uniqKey="Abdelwhab E" first="El-Sayed M" last="Abdelwhab">El-Sayed M. Abdelwhab</name><name sortKey="Kuznetsova, Irina" sort="Kuznetsova, Irina" uniqKey="Kuznetsova I" first="Irina" last="Kuznetsova">Irina Kuznetsova</name><name sortKey="Pleschka, Stephan" sort="Pleschka, Stephan" uniqKey="Pleschka S" first="Stephan" last="Pleschka">Stephan Pleschka</name><name sortKey="Schuttler, Christian G" sort="Schuttler, Christian G" uniqKey="Schuttler C" first="Christian G" last="Schüttler">Christian G. Schüttler</name><name sortKey="Slanina, Heiko" sort="Slanina, Heiko" uniqKey="Slanina H" first="Heiko" last="Slanina">Heiko Slanina</name><name sortKey="Ziebuhr, John" sort="Ziebuhr, John" uniqKey="Ziebuhr J" first="John" last="Ziebuhr">John Ziebuhr</name></country><country name="Égypte"><noRegion><name sortKey="Mostafa, Ahmed" sort="Mostafa, Ahmed" uniqKey="Mostafa A" first="Ahmed" last="Mostafa">Ahmed Mostafa</name></noRegion><name sortKey="Hussein, Mohamed A" sort="Hussein, Mohamed A" uniqKey="Hussein M" first="Mohamed A" last="Hussein">Mohamed A. Hussein</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeAllemagneV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000093 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000093 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeAllemagneV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26973232
|texte= Phylogenetic analysis of human influenza A/H3N2 viruses isolated in 2015 in Germany indicates significant genetic divergence from vaccine strains.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26973232" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeAllemagneV4
| This area was generated with Dilib version V0.6.35. |  |